Researchers said psychotic disorders are associated with increased levels of dopamine a chemical released by nerve cells in a subregion of the brain called the
striatum. This area is wired to process positive versus negative feedback for learning, often resulting in a person's thoughts and actions based on what they've experienced in the past.
These dopaminergic neurons are situated in the nigrostriatal pathway, which is a brain circuit that connects neurons in the substantia nigra pars compacta with the dorsal
striatum.
AAV5-miC injected into the
striatum of ALS mice reduced mutated C9orf72 in the transduced areas.
For the study the team examined a region deep within the brain called the ventral
striatum in 1,129 college students.
The measurements were performed in three areas of the surrounding tissue of the host's
striatum for both transplanted (Figure 1a-1d) and shamtransplanted animals (Figure 1b), according to the scheme by Jonas et al.
Presynaptic hypothesis regained its popularity with the findings of human imaging studies showing that LID are more common in patients with larger fluctuations of dopamine levels in the
striatum with standard L-dopa treatment and other experimental studies showing that presynaptic dopaminergic compartment plays a major role in determining the susceptibility to LID (6,7).
Our collection of six is made up of one of each of these varieties: Sanguineum
Striatum, Johnson's Blue, Cinereum Ballerina, Karmina, Sanguineum Alba and Cinereum Giuseppe.
The basal ganglia are a group of subcortical gray nuclei, which include the dorsal
striatum [i.e., caudate nucleus (CAU) and putamen (PUT)], ventral
striatum [including the nucleus accumbens (NA)], globus pallidus (GP), substantia nigra (SN), and subthalamic nucleus (STN), and have complex anatomical and functional projections in the brain (1,2).
Multiple hypotheses have been proposed to explain the antiparkinsonian effects of zonisamide [9, 10]; however, it is still unclear whether the effect of zonisamide is mainly due to dopaminergic modification in the
striatum, or if zonisamide works through nondopaminergic pathways.
At 2 weeks and 8 weeks after STZ injection, the hippocampus, prefrontal cortex, and
striatum of the mice in the CON and T1DM groups were prepared for the determination of PKC isoform expression levels and membrane translocation of PKC isoforms (n = 6 per group, resp.).