A 2016 quantitative analysis of Psoralea corylifolia and seven of its standard constituents (
psoralen, angelicin, neobavaisoflavone, psoralidin, isobavachalcone, bavachinin, and bakuchiol) using high-performance liquid chromatography revealed that bakuchiol is the strongest phytochemical ingredient in the plant, which the investigators found also confers neuroprotective and antineuroinflammatory benefits.
Linear scleroderma 'en coup de sabre' treated with topical calcipotriol and cream
psoralen plus ultraviolet A.
The most widely prescribed therapies in all cases of vitiligo are topical corticosteroids and phototherapy including PUVA (
psoralen combined with ultraviolet A) and NBUVB (narrow band ultraviolet B)3.
However, Lomatium foeniculaceum, Iva axillaris,
Psoralen argophylla and Antennaria parvifolia were more common on heavy soils, while Astragalus missouriensis and Allium textile were better represented on light soils (Table 2).
In the European Union, ustekinumab is approved for the treatment of moderate to severe plaque psoriasis in adults who failed to respond to, who have a contraindication to, or are intolerant to other systemic therapies including ciclosporin, methotrexate or
psoralen plus ultraviolet A, and is also indicated for the treatment of moderate-to-severe plaque psoriasis in adolescent patients from the age of 12 years and older who are inadequately controlled by, or are intolerant to, other systemic therapies or phototherapies.
corylifolia, Bakuchichin (13), isopsoralen (14) and
psoralen (15) were subjected for docking studies.
Several treatment options, such as melphalan, IVIG, systemic steroids, oral retinoid, thalidomide, cyclophosphamide, cyclosporine, and methotrexate administration;
psoralen and ultraviolet A radiation; plasmapheresis; autologous stem cell transplantation; electron radiotherapy; and extracorporal photopheresis, have been described in the literature (9).
The dose of acitretin was increased to 50 mg/d at the last admission and
psoralen and ultraviolet A (PUVA) therapy was started.
Some patients responded to ammonium lactate lotion, the per oral retinoid and
psoralen plus ultraviolet A therapy.
Psoralen and isopsoralens are a class of molecules which can be added to a PCR reaction during setup, and which at suitably low concentrations--roughly, below 100mg/ml--don't noticeably inhibit the PCR reaction.
In vitro isolation, elicitation of
psoralen in callus cultures of Psoralea corylifolia and cloning of
psoralen synthase gene.
Various treatment modalities, including immunosuppressants like corticosteroids and methotrexate, electron beam radiotherapy, tamoxifen,
psoralen plus ultraviolet A (PUVA) therapy, and ultraviolet A1 phototherapy, have been used for SD with mixed and inconsistent results [16-21].