adduct

Termini and his team analyzed mice with diabetes to see how elevated blood glucose levels can cause a DNA damage, called adducts. The researchers found that the adduct, N2-(1-carboxyethyl)-2'-deoxyguanosine (CEdG), appeared high in diabetic animals.A

Termini and his colleagues looked for a specific type of damage in the form of chemically modified DNA bases, known as adducts, in tissue culture and rodent models of diabetes.

The principle of action of Cisplatin in combating cancer involves exerting its cytotoxicity upon cancer cells through the formation of DNA adducts that include mono-, inter, and intrastrand cisplatin DNA cross-links that arrest the cell cycle at S, G1 or G2-M thus induces apoptosis.

The team now plans to replicate the study on a larger scale, to see how the level of DNA adducts differs between e-cigarette users and regular cigarette users.

Mao-wen Weng, Ph.D., from New York University in New York City, and colleagues evaluated DNA adducts induced by the three major tobacco smoke carcinogens: benzo(a)pyrene (BP), 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanoe (NNK), and aldehydes in humans and mice.

Adducts based on methylcyclohexyl diamine (MCDA, Baxxodur[R] EC 210), a cycloaliphatic diamine curative for epoxy resin systems, displayed enhanced carbamate stability compared to adducts based on both isophorone diamine (IPDA) and m-xylylene diamine (MXDA).

In babies born pre-closure, researchers found higher levels of PAH-DNA cord adducts, a biomarker for exposure to polycyclic aromatic hydrocarbons, a toxic component of air pollution from coal plants.

A wide class of self-healing materials is based on Diels-Alder polymers, macromolecular architectures with reversible bonds due to the presence of Diels-Alder adducts incorporated into the polymer networks [8].

Biomarkers of internal exposure to PAHs include urinary 1-hydroxypyrene (1-OHP) [11,12], and PAH-DNA (deoxyribonucleic acid) and PAH-protein adducts, and in effect biomarkers include DNA damage, chromosomal aberrations, sister chromatid exchanges and micronuclei.

Investigation for DNA adducts by analysis of genomic DNA from leucocytes by gas-liquid chromatography showed the presence of epoxy-oleic acid, which was localised to the N-formyl peptide receptors (FPRs) using DNA microarrays.

The [rho] and [[nabla].sup.2][rho] parameters at the bond critical points (BCPs) concerning dipole polarizability tensors were calculated based on the optimized structures (taking into consideration the already calculated interaction energy) using the AIM approach and applying B3LYP/6-31G(d,p) (adducts 7AlaB, 7LysB, 7GluB, and 7MetB), B3LYP/6-311+G(d,p) (adducts 7GluB6 and 7MetB6), PBE0/6-31G(d,p) (adducts 7LysP), and M06L/6-31G(d,p) (adduct 7AlaM) levels of theory, respectively.